芦丁缓释骨架片释药机制影响因素考察

A Study of the Factors Influencing the Release Mechanism of Rutin from Sustained-release Matrix Tablets

目的 :考察芦丁缓释骨架片释药机制的影响因素。方法 :以羟丙基甲基纤维素 (HPMC)为骨架材料制备缓释骨架片 ,利用Peppas经验式释放指数n值 ,评价HPMC、微晶纤维素 (MCC)、可压性淀粉用量对芦丁缓释骨架片体外释药机制的影响。结果 :释药速率随HPMC含量增高而减慢 ,MCC和可压性淀粉的加入均加快芦丁释药速率。结论 :HPMC、MCC、可压性淀粉的用量对释药机制均有影响 ,以HPMC用量影响较大。

Objective:To study the factors influencing the release mechanism of rutin from sustained release matrix tablets. Methods:The sustained release matrix tablets of rutin were prepared by using hydroxypropylmethyl cellulose (HPMC) as the matrix material. The effects of the amounts of HPMC, microcrystalline cellulose (MCC) and pregelatinized starch on the in vitro drug release of rutin from the sustained release matrix tablets were appraised with the release index n value of the Peppas empirical formula. Results:The rate of drug release was slowed down along with the increase of the content of HPMC. Addition of both MCC and pregelatinized starch speeded up the rate of rutin release from the tablets. Conclusion:The contents of HPMC, MCC and pregelatinized starch were shown to influence the release mechanism of rutin. Among these, the content of HPMC appeared to have the most pronounced effect.