郑州地区输血相关疾病的调查

Investigate transfusion related disease in Zhengzhou area

目的 :调查郑州地区输血相关疾病阳性率分布情况。方法 :除血型采用凝集法以及HBV_DNA和HCV_RNA采用荧光定量PCR法外 ,其余检测项目均采用ELISA法。利用Excel对检测结果进行分析。结果 :郑州地区无偿献血人群中 ,抗_HCV阳性率为 1 11% ,女性抗_HCV阳性率高于男性 ( χ2 =9 60 15 ,P <0 0 5 ) ;TRUST阳性率为 0 12 % ,女性比男性更易感染梅毒 ( χ2 =7 6991,P <0 0 5 ) ;ALT和脂血淘汰率最高 ( 3 2 6%和 2 3 1% ) ,ALT阳性率男女有极显著差异 ( χ2 =16 7418,P <0 0 0 1) ,ALT阳性率男性是女性的 5倍 ,ALT阳性率夏季高于其它季节 2个百分点 ,大中专学生ALT阳性率最低 ;无偿献血人群中存在艾滋病携带者 ;HB sAg经街头快速初筛后其漏检率 ( 1 0 6% )男女无显著差别 ( χ2 =2 7991,P >0 0 5 ) ;郑州地区ABO血型分布为B >O >A >AB ,Rh阴性率为 0 3 6% ,接近我国汉族人群的分布值 ,建立了 42 4名Rh阴性的稀有血型档案库 ;抗_HGV的阳性率为 1 42 % ;在无偿献血者中未发现HTLV阳性者 ;抗_TTV阳性率为 4 17% ;HCV_RNA和HBV_DNA阳性率分别为 0 0 8%和 0 2 5 % ;输血反应发生率为 0 2 9%。结论 :郑州地区无偿献血人群中输血相关疾病属于低发病区 ,建议增加HBV、HCV。

Objective: The authors investigate distribution of transfusion related disease positive rate in zhengzhou area.Methods: The authors detect the blood samples using ELISA,except that blood types are detected using coagulate assay and HBV-DNA and HCV-RNA are detected using FQ-PCR.The authors analysis detected results using Excel.Results: In the volunteer donors of Zhengzhou area,the positive rate of anti-HCV is 1.11%,the positive rate of female anti-HCV higher than male (χ 2=9.6015,P<0.05);The positive rate of TRUST is 0.12%,female infect syphilis easier than male (χ 2=7.6991,P<0.05);The disusing rate of ALT and fat blood is highest in these (3.26%和2.31%),the positive rate of ALT have difference between male and female (χ 2=16.7418,P<0.001),the positive rate of male ALT is five times higher than female,the positive rate of ALT is 2% higher than the other season,the positive rate of the students ALT is very low;The volunteer donors have infected HIV;HBsAg after street is quickly early screening,the rate of its leaked to detect(1.06%) have no difference between male and female (χ 2=2.7991,P>0.05);Blood types distribution is B>O>A>AB in zhengzhou area,the rate of Rh(-) is 0.36%,near to Chinese peoples distribution,the authors establish the bank of 424 Rh(-) blood types donors;The positive rate of anti-HGV is 1.42%;The authors don't find HTLV positive in the volunteer donors;The positive rate of anti-TTV is 4.17%;The positive rate of HCV-RNA and HBV-DNA is 0.08% and 0.25%;The ccurrence rate of transfusion responds is 0.29%.Conclusion: The volunteer donors in zhengzhou infected transfusion related disease belong to the low area.The authors suggest that the volunteer donors increase HBV HCV and HIV nucleic acid detecting technology and that the volunteer donors increase to detect HGV and TTV item.