120例急性有机磷杀虫剂中毒患者的随访研究

A follow-up study on 120 cases of acute organophosphorus pesticides poisoning

目的 探讨口服有机磷杀虫剂中毒者的远期临床结局及影响因素。方法 以山东省滕州和郓城两县医院 1 999年收治的口服有机磷杀虫剂自杀未遂者 1 32例为研究对象 ,于 2 0 0 1年 7～1 0月到患者家庭所在地进行以医院为基础的随访调查。采用面对面问卷调查及体检 ,调查患者中毒2年来有机磷迟发性神经病 (OPIDP)的发生情况 ,并用生命质量量表评价其生命质量。结果 1 32例患者共随访到 1 2 0例 ,发生OPIDP 1 1例 ,发生率为 9 1 7%。OPIDP的发生率与中毒程度有关 ,重度中毒可增加OPIDP发生的危险性 (RR =1 1 6 4 ,95 %CI为 1 0 3～ 1 32 )。 1 1例OPIDP患者中毒 2年后其身体状况、精神心理状况、经济状况评分及生命质量总评分与中毒前 1个月内比 ,差异均有显著性 (P<0 0 5 )。结论 OPIDP的发生率与中毒程度有关 ,OPIDP患者的生命质量较差。

Objective To investigate the long term clinical outcomes of acute oral organophosphorus (OPs) poisoning and related influence factors. Methods A total of 120 cases of suicidal oral acute OPs poisoning admitted in Tengzhou and Yuncheng county hospitals in Shandong province in 1999 were followed in 2001 by interview and physical examination. Results Organophosphate induced delayed polyneuropathy (OPIDP) were detected in 11 cases and the prevalence of OPIDP was 9 17% (11/120). The incidence of (OPIDP) increased with the poisoning severity ( RR=1 16,95% CI =1 03-1 32). Conclusion There was a positive correlation between the prevalence of OPIDP and the severity of OPs poisoning.