苦参碱治疗慢性乙型肝炎疗效观察

Clinical Observation on Matrine in Treatment of Chronic Hepatitis B

目的 观察苦参碱注射液治疗慢性乙型肝炎的临床效果。 方法 对 76例慢性乙型肝炎患者随机分为治疗组和对照组 ,对照组给予茵栀黄注射液 ,治疗组给予苦参碱注射液 ,两组辅助用药为维生素类。结果 两组对纳差、乏力ALT下降方面疗效相似达 80 % ,对腹胀和肝区痛 ,治疗组分别为 96 %和 87% ,对照组分别为 75 %和 6 2 % ,有显著差异 ,对SB消退和HBeAg阴转率方面 ,治疗组分别为 90 %和 5 1% ,对照组为 5 5 %和 2 8% ,P <0 0 1,两组有显著性差异。 结论 苦参碱注射液治疗慢性乙型肝炎有很好的效果 ,特别对退黄和HBeAg阴转方面尤为显著 。

Objective To observe the clinical efficacy of matrine on the treatment of chronic hepatitis B.Methods Seventy-six patients with chronic hepatitis B were randomly divided into treatment group and control group.Control group were treated with Yinzhihuang and vitamin,treatment group were treated with matrine and vitamin.Results Two groups in aspect of appetite reduction and lack power and ALT reduction,the effective rate was 80%.abdominal distension and ache of liver area,the effective rate were 96% and 87% in the treatment group,in control group were 75% and 62%,they were significant difference.on SB reduction and HBeAg negative-transformed rate were 90% and 51% in the treatment group.That in control group were 55% and 28%(P<0.01), there were significant difference.Conclusion The results show that matrine has very good effect in the treatment of chronic hepatitis B,particularly to SB reduction and HBeAg negative-transformed rate,matrine is worth popularizing and applying.