肝细胞生长因子在急性肾功能衰竭患者血清中的表达

Expression of serum hepatocyte growth factor in patients with acute renal failure

目的 :探讨急性肾功能衰竭 (ARF)患者血清中肝细胞生长因子 (HGF)的表达及其临床意义。方法 :用ELIAS方法测定 31例急性肾衰竭患者不同时期和 2 8例健康人血清HGF水平。结果 :ARF患者少尿期、多尿期血清中的HGF水平均明显高于健康人 (P <0 .0 0 1) ,以少尿期上升最明显 ,随后呈下降趋势 ,至恢复期接近健康人水平 (P >0 .0 5 )。急性肾功能衰竭患者各时期血清中的HGF水平与血肌酐 (SCr)和尿素氮 (BUN)呈正相关 (r =0 .74 1,P <0 .0 0 1;r=0 .76 3,P <0 .0 0 1)。结论 :ARF患者血清HGF水平显著上升 ,与肾功能受损的程度呈正相关。血清HGF的变化可帮助了解肾损害严重程度 。

Objective To investigate the changes of serum hepatocyte growth factor (HGF) in patients with acute renal failure (ARF) and to evaluate the clinical value. Methods Serum HGF levels were determined by ELISA in 31 patients with ARF at the stages of oliguria, polyuria and convalescence and in 28 healthy controls. Results Compared with the controls, the HGF levels in the serum increased significantly in the ARF group at the stages of oliguria and polyuria, while the serum HGF returned to normal levels at the convalescence stage. There was significant positive correlation between the serum HGF and BUN or SCr in the ARF group.Conclusion Serum HGF in ARF patients increased significantly and tended to rise at first but dropped afterwards, which reflected the course of renal injury and the recovery of renal epithelial cells.