乳腺癌nm23蛋白表达的相关因素及其骨转移危险因素分析

Relevant factors of nm23 protein expression and dangerous factors of bone metastasis in breast cancer

目的 :探讨乳腺癌nm2 3蛋白表达的相关因素及其发生骨转移的危险因素。方法 :76例接受手术治疗的乳腺癌患者 ,对其乳腺癌组织作半定量nm2 3蛋白测定。乳腺癌nm2 3蛋白表达的相关因素及其骨转移的危险因素用成组资料logistic回归分析。结果 :5 8例观察期间未发生骨转移的乳腺癌患者 ,经判别 5 5例未发生骨转移 ,判别正确率 94 .83% ;18例发生骨转移者 ,经判别 14例发生骨转移 ,判别正确率 77.78% ;总正确率 90 .79%。结论 :乳腺癌nm2 3蛋白检测有利于判断预后 ;有利于补充和完善治疗方案 ;

Objective To investigate the relevant factors of the expression of nm23 protein and the dangerous factors of bone metastasis in breast cancer.Methods Seventy-six breast cancer patients confirmed by histological examination after surgeries were enrolled in this study. nm23 protein expressions in original breast cancer tissues were detected by immunohistochemical procedures. The relevant factors of nm23 protein expression and the dangerous factors of bone metastasis were conducted logistic regression analysis. Results Among the 58 breast cancer patients who did not have bone metastasis in the observation period, 55 did not have bone metastasis;while the other 18 breast cancer patients having bone metastasis were confirmed in only 14 patients. The correction was 94.83% and 77.78% respectively. The general correction was 90.79%. Conclusion The detection of nm23 protein is helpful to evaluate prognosis and improve the therapy. It is one of the important methods to instruct the breast cancer patients to perform radio-nuclide imaging in the follow-up.