期刊文献+

海洛因所致肾损害与横纹肌溶解症 被引量:5

Heroin-induced Renal Damage and Rhabdomyolysis
下载PDF
导出
摘要 目的 :通过实验研究揭示海洛因成瘾与由之所致肾损害及横纹肌损害之间的关系 .方法 :应用免疫组织化学及透射电镜扫描的研究方法 ,对 11例海洛因成瘾尸体肾脏及腓肠肌组织进行透射电镜观察 .结果 :肾组织免疫组织化学研究 ,11例中 6例检出肌红蛋白成份 ;对上述尸体肾脏及腓肠肌进行透射电镜扫描观察 ,不同程度地显示了一定的形态学特征 .结论 :肾组织中肌红蛋白的检出 ,揭示了海洛因滥用及其所致肾损害和横纹肌损害之间的关系 ,指出海洛因所致横纹肌溶解症的存在及其与海洛因成瘾者临床肌痛之间的关系 .强调在海洛因所致横纹肌溶解症死者的肾脏组织中 ,如若采用免疫组织化学的方法可检出肌红蛋白的成份 . The renal tissue in eleven heroin addicts was studied by immunohistochemical technique and the myoglobin was demonstrated in six of them. The kidney, soleus and myocardium were studied using transmission electron microscopical technique (TEM) as well. The presence of myoglobin in kidney and the related changes on striped muscle documented the relation between the renal damage and rhabdomyolysis in heroin addiction. The effects of heroin on other tissues were observed grossly and microscopically.
出处 《昆明医学院学报》 2004年第1期1-8,共8页 Journal of Kunming Medical College
基金 云南省自然科学基金资助项目 (97CO5 7M)
关键词 海洛因 肾损害 横纹肌溶解症 免疫组织化学 透射电镜扫描 Morphological observation Rhabdomyolysis Myoglobin Immunohistochemistry Electron microscopy Striped muscle Kidney Heroin
  • 相关文献

参考文献22

  • 1[1]RICHTER R W, ROSENBERG R N. Transverse myelitis associated with heroin addiction[J]. JAMA,1968, 206: 1255
  • 2[2]RICHTER R W, CHALLENOR Y B, PEARSON J. Acute myoglobinuria associated with heroin addiction, abstracted[J]. Clin Res,1970, 18:695
  • 3[3]AMOIRIDIS G,SCHOLS L. Drug-induced rhabdomyolysis and lesions of peripheral nerves. Sequelae of local ischemia within the scope of circulatory collapse[J]. Nervenarzt, 1996, 67(12): 1023
  • 4[4]KUMAR P,TOUQUET R. Perils of the recovery position: Neurapraxia of radial and common personal nerve[J]. Journal of Accident and Emergency Medicine,1996, 13 (1): 69
  • 5[5]KOFFLER A, FRIEDLER R M, MASSRY S G. Acute renal failure due to nontraumatic rhabdomyolysis[J]. Ann Intern Med, 1997, 137:1255
  • 6[6]NICHOLLS NIALL J F, MORAN J E. Rhabdomyolysis and renal failure[J]. Med J Aust, 1982, 2:387
  • 7[7]GIBB W R G, SHAW J C. Myoglobinuria due to heroin abuse[J]. JR Soc Med, 1985, 78:862
  • 8[8]YANG C C, YANG G Y. Severe rhabdomyolysis mimicking transverse myelitis in a heroin addict[J]. Journal of Toxicology-Clinical Toxicology, 1995, 33:591
  • 9[9]PENA J, ARANDA C, LUQUE E, et al. Heroin-induced myopathy in rat skeletal muscle[J]. Acta Neuropathologica, 1990, 80:72
  • 10[10]PENA J, LUQUE, ARANDA C, et al. Experimental herion-induced myopathy: ultrastructrual observation[J]. Journal of Sumicroscopic Cytology and Pathology, 1993, 25:279

同被引文献22

  • 1郝桂芳,李辉.海洛因中毒致急性呼吸衰竭的救治(附98例报告)[J].中国临床医学,2004,11(3):344-345. 被引量:5
  • 2遇红梅,洪敏,孙聪,张纪周,杨宇丹,付海英,程丕显,郭艳霞.海洛因对大鼠脾中腺苷脱氨酶、黄嘌呤氧化酶和血尿酸的影响[J].吉林大学学报(医学版),2005,31(3):404-406. 被引量:5
  • 3王娜,吴红海,侯艳宁.吗啡依赖和复吸时大鼠脑内神经甾体水平的变化[J].中国药理学通报,2006,22(6):727-730. 被引量:4
  • 4Richter RW, Challenor YB, Pearson J,et al. Acute myoglobinuria associated with heroin addiction.JAMA 1971;216(7):1172-6
  • 5Hsu SM, Werner A, Griffiths G,et al.Demonstration of myoglobin in formalin-fixed renal sections by immunoperoxidase technic.Am J Clin Pathol 1982;77(3):316-9
  • 6Johnson J E,White J J,Walovitch R C,et al.Effects of morphine on rat kidney glomerular podocytes:a scanning electron microscopic study[J].Drug Alcohol Depend,1987,19(3):249-57.
  • 7Atici S,Cinel I,Cinel L,et al.Liver and kidney toxicity in chronic use of opioids:an experimental long term treatment model[J].J Biosci,2005,30(2):245-52.
  • 8Singhal P C,Pan C Q,Sagar S,et al.Morphine enhances deposition of ferritin-antiferritin complexes in the glomerular mesangium[J].Nephron,1995,70(2):229-34.
  • 9Enrico P,Mura M A,Esposito G,et al.Effect of naloxone on morphine-induced changes in striatal dopamine metabolism and glutamate,ascorbic acid and uric acid release in freely moving rats[J].Brain Res,1998,797(1):94-102.
  • 10Enrico P,Esposito G,Mura M A,et al.Effects of allopurinol on striatal dopamine,ascorbate and uric acid during an acute morphine challenge:ex vivo and in vivo studies[J].Pharmacol Res,1997,35(6):577-85.

引证文献5

二级引证文献13

相关作者

内容加载中请稍等...

相关机构

内容加载中请稍等...

相关主题

内容加载中请稍等...

浏览历史

内容加载中请稍等...
;
使用帮助 返回顶部