后肾性腺瘤3例分析

Metaniphric Adenoma:A Report of 3 Cases

目的 :探讨后肾腺瘤的临床、病理学特征及诊断要点 .方法 :收集 3例后肾腺瘤的临床资料 ,手术切除标本 ,采用常规HE染色 ,SP法免疫组化染色 ,结合复习文献进行讨论 .结果 :临床表现不典型 ;组织学主要由紧密排列的小管状、乳头状腺体构成 ,其间含有肾小球样结构 .免疫组化结果 :Leu7(+) ,Vi mentin (+) ,CK7灶性 (+) ,EMA (+) ,CK (- ) .结论 :后肾性腺瘤是肾胚胎残留发生的罕见良性肿瘤 ,常被误诊为恶性肿瘤 ,应与肾母细胞瘤、乳头状肾细胞癌、神经内分泌肿瘤。

Objective: To seek the clinical and histopathological characteristics of the metanephric adenoma and the criteria for its pathological diagnosis. Methods: 3 cases were stained with HE and immunohistochemistry. Results: The clinical features of metanephric adenoma were not typical, and these tumors consist of tubular, papillary and glomeruloid-like formation. Immunohistochemically, Leu7 and vimentin were positive, CK7 was focally positive, the EMA, Cga, Syn and S-100 were negative. Conclusion: Metanephric adenoma is a rare benign tumor that originates from the remnants of early metanephric tissues and is often diagnosed as malignancy. It occurred mainly in youth and middle-aged female. It is very important to distinguish it from Wilms' tumor, renal cell carcinoma, neuroendocrine tumor, nephroblastomatosis and nephrogenic rests.