基质金属蛋白酶-2、-7在肺癌中的表达

Expression of MMP-2 and MMP-7 in lung cancer and its significance

目的 探讨肺癌组织中基质金属蛋白酶 2 (MMP 2 )和基质金属蛋白酶 7(MMP 7)的表达及意义。方法 采用免疫组化S P法检测手术切除的 2 0例癌旁正常肺组织、74例肺癌组织中MMP 2和MMP 7的表达。结果 肺癌组织中MMP 2和MMP 7表达均显著高于癌旁正常肺组织 (各为P <0 .0 1 ,<0 .0 5 )。肺癌MMP 2表达有淋巴结转移者高于无淋巴结转移者 (P <0 .0 1 ) ,Ⅲ～Ⅳ期高于Ⅰ～Ⅱ (P <0 .0 5 )。肺癌MMP 7表达与有无淋巴结转移无明显相关性 (P >0 .0 5 ) ,Ⅲ～Ⅳ期与Ⅰ～Ⅱ期相比较差异无显著性 (P >0 .0 5 )。单变量分析显示MMP 2表达阳性者生存率低于MMP 2阴性者 (P <0 .0 1 )。结论 MMP 2与肺癌侵袭转移密切相关 ,可作为判断肺癌预后的有用指标。MMP 7可能在肺癌侵袭转移中作用不显著。

Objective To investigate the expression of MMP 2 and MMP 7 in lung carcinoma tissue and its significance. Methods The expression of MMP 2 and MMP 7 was detected in 74 lung carcinoma tissues and 20 para cancerous normal lung tissues by immunohistochemical method.Results The expression of MMP 2 and MMP 7 in lung cancer tissues was significantly higher than that in para cancerous normal lung tissues( P <0.01, P <0.05).The expression of MMP 2 was significantly higher in lung carcinomas with lymph node metastasis than that in lung carcinomas without lymph node metastasis( P <0.01),and was significantly higher in stage Ⅲ and Ⅳ tumours than that in stage Ⅰand Ⅱ tumours( P <0.05).The expression of MMP 7 in lung carcinomas was not associated with the presence of lymph node metastasis( P >0.05),and there was no statistical difference between stage Ⅲ and Ⅳ tumours and stage Ⅰ and Ⅱ tumours( P >0.05).Univariate analysis showed a close association of MMP 2 expression with shortened survival( P <0.01).Conclusion The expression of MMP 2 is closely correlated with the invasion and metastasis of lung carcinoma,and MMP 2 may be used as a predicting marker of the prognosis of lung carcinoma.The expression of MMP 7 may be not a critical factor which affects the invasion and metastasis of lung carcinoma.