恶性组织细胞病的早期诊断

Early diagnosis of malignant histiocytosis

目的对恶性组织细胞病 (MH )的临床症状、病理特征进行分析 ,以提高早期诊断率。方法对本院收治的 16例、文献报道的 184例进行回顾性分析 ,总结出影响早期诊断的相关因素。结果MH早期临床表现为多系统受累 ,有发热 ( 96% )、肝大( 80 % )、脾大 ( 72 .5 % )、淋巴结肿大 ( 5 2 % )等 ,病理上主要为异型组织细胞增生。结论本组病例提示 ,根据病史和实验室检查 。

Objective Clinical symptoms and pathological features of malignant histiocytosis (MH) were analyzed to obtain early diagnosis in clinical practice.Methods A retrospective analysis was performed on 16 hospitalized cases of MH and 184 reported cases on literature.Results At early stage of MH, it was manifested by multi-system involvement, fever(96%), hepatomegaly, splenomegaly and lymphadenectasis. Pahtologically, it showed heteromorphic histiocyte hyperplasis.Conclusions The findings of this study suggested that history and laboratory tests, especially multi-site bone marrow puncture should be able to improve the rate of early diagnosis.