复方丹参注射液预防大鼠术后腹腔粘连的实验研究

Experimental study of postoperative intra-abdominal cavity adhesion prevented with compound Danshen injection in rats

目的 观察复方丹参注射液对大鼠术后腹腔内粘连的预防作用。方法 选择 48只SD大鼠 ,制作一种术后腹腔内粘连的模型。术后随机分为 4组 ,关腹前腹腔灌注大、小剂量的复方丹参注射液、地塞米松注射液、生理盐水注射液 ,术后第 10天进行大体粘连程度分级。结果 两个剂量复方丹参注射液组术后腹腔内粘连的程度均小于地塞米松组和生理盐水对照组。

ObjectiveIt is to observe the preventive effect o f comp ound Danshen injection on postoperative intra-abdominal cavity adhesion in rats .Methods48 SD rats were chosen and made models of postoperative intra-abdominal cavity adhesion. The rats were randomly divided into four groups and respectivel y perfused big-dose compound Danshen injection, small-dose compound Danshen inj e ction, Dexamethasonum injection and physiological saline injection in abdominal cavity before the abdominal cavity were shut. The general degrees of adhesion we re graded on the tenth day after operation.Results The general degrees of adhesion in the compound Danshen injection groups were smaller than those in Dexamethasonum group and physiological saline contro l group.Conclusion The preventive effect of compound Danshen injection o n postoperative intra-abdominal cavity adhesion is effective.