谷氨酰胺在感染状态下的代谢

Glutamine metabolism in sepsis and infection

严重感染时 ,器官中谷氨酰胺代谢发生显著改变。骨骼肌合成和释放谷氨酰胺均增加 ,但释放明显大于合成 ;肝成为谷氨酰胺最主要的摄取器官 ;而肠道对谷氨酰胺的利用减少 ;

Sepsis causes marked derangements in the flow of glutamine among organs.During sepsis,skeletal muscle exhibits increase in glutamine release which is associated with a significant increase in endogenous glutamine biosynthesis.However, the release rates exceed that of synthesis.The liver appears to be the major organ of glutamine uptake,the bowel displays a decrease in glutamine utilization and the cells of the immune system are also major glutamine consumers.