支原体感染与生殖细胞硫酸半乳糖甘油酯的关系

Relationship between Mycoplasma Infection and Germ Cell Sulfogalactosylglycerolipid

支原体不仅能引起男性生殖道感染 ,而且某些支原体如溶脲脲原体 (Uu)和一些不明原因的男性不育密切相关。硫酸半乳糖甘油酯 (SGG)是主要存在于哺乳动物生精细胞和精子上的一种硫酸糖酯 ,由早期初级精母细胞合成 ,通过与卵细胞上的配体———芳基硫酸酯酶 (AS A)的结合而参与精卵识别。近来发现 ,支原体能与SGG结合 ,使后者发生脱硫作用成半乳糖甘油酯 ,阻断SGG与AS A的结合 ,从而影响精卵的识别与结合 ,可能是Uu感染导致不育的原因之一。

It is well known that mycoplasma can cause infection in the male reproductive tract. Some studies indicate that Ureaplasma urealyticum (Uu),a species of mycoplasma,is associated with male infertility. Sulfogalactosylglycerolipid(SGG) is the major mammalian male germ cell glycolipid, synthesized via sulfation of galactosylglycerolipid in early primary spermatocytes. Some experiments have proved that SGG is implicated in sperm egg binding by linking arylsulfatase A (AS A), SGG's ligand on the egg. SGG can be desulfated by binding mycoplasmas and transformed galactosylglycerolipid, which doesn't bind AS A. So the binding and degradation of the sperm SGG by mycoplasmas may play a role in the induction of male infertility. As a kind of mycoplasma, Uu can also bind SGG, which offers another explantion for the association of Uu infection with male infertility caused by Uu infection.