前列腺癌骨转移性疼痛的综合治疗

Combined Treatment for Pain from Bone Metastases in Patients with Prostate Cancer

目的 :探讨晚期前列腺癌骨转移性疼痛的综合治疗方法。 方法 :16例确诊为前列腺癌且有多个部位骨转移病灶伴有疼痛的患者 ,采用口服抗雄激素药物治疗的同时 ,辅以核素89Sr静脉内注射治疗和部分病灶放射治疗。 结果 :治疗后 ,疼痛缓解率 3个月为 75 .6 % ,6个月为 80 .5 % ,9个月为 6 3.4 % ;骨转移病灶数量明显减少。结论 :经过综合治疗后 ,本组晚期前列腺癌伴骨转移性疼痛的患者疼痛获得较为满意的缓解、甚至消失 ,从而改善了患者的生活质量。

Objective: To evaluate the effects of combined treatment of hormone therapy with strontium 89 for pain from bone metastases in patients with prostate cancer. Methods: Sixteen patients with metastasis prostate cancer received hormone therapy with strontium 89 chloride ( 89 Sr), and 4 of them received radiotherapy. Results: The pain was relieved. Relief occurred in 75.6 % of the patients for 3 months, 80.5 % for 6 months and 63.4 % for 9 months. Conclusion: Hormone therapy enhances the effect of 89 Sr without obvious toxicity. The combined treatment not only significantly raises pain palliation, prolongs pain free survival, but improves the patients' life quality.