生脉散加味联合慢心律治疗频发室性早搏27例

Clinical Analysis of 27 Patients with Frequent Ventricular Extrasystole Treated with Pulse-activating Powder and Mexiletine

目的 观察生脉散加味联合慢心律治疗频发性室性早搏的临床疗效 ,并初步探讨其作用机制。方法 将经过 2 4h长程心电图确诊为频发性室性早搏的 5 1例患者 ,随机分为治疗组和对照组 ,对照组口服慢心律 ,治疗组在服用慢心律的基础上 ,以生脉散为基本方 ,随证加味用药。 1周为 1个疗程。结果 治疗组显效率 33.3% ,总有效率 88.9% ,无加重病例 ;对照组显效率 1 6 .7% ,总有效率 6 2 .5 % ,加重 3例。治疗组优于对照组 ,有显著性差异 (P <0 .0 5 )。

Objective To observe the effect of Pulse activating Powder and antiarrhythic drug (mexiletine) treating frequent ventricular extrasystole to attempt to discuss its therapeutic mechanism. Methods 51 cases diagnosed frequent ventricular extrasystole by 24 h DCG (dynamic electrocardiogram) were randomly separated into two groups.Treatement group was treated with mexiletine (same as the control group) and Pulse activating Powder one dose per day.Control group treated with mexiletine.A period of treatment was 7 days. Results In the trentament group,significant effective was 9 cases (33.3%),the total effective was 24 cases (88.9%),and no adverse reaction.In the control group ,significant effective was 4 cases (16.7%),total effective was 15 cases (62.5%),and 3 cases had adverse reaction (naupathia,hypopiesia).The difference of effects was significant between two groups (P<0.05). Conclusion Pulse activating Powder and mexiletine relieved clinical symptom and reduced the frequence of ventricular extrasystole is better than only using mexiletine.