血管形成抑制剂TNP-470对小鼠肝癌术后复发和转移防治的研究

EXPERIMENTAL STUDY OF PREVENTION AND TREATMENT EFFECT OF TNP-470 ON THE RECURRENCE AND METASTASIS OF THE MICE BEARING HEPATOCELLULAR CARCINOMA

目的 研究血管形成抑制剂TNP 470对小鼠原位移植性肝癌术后复发和转移的防治作用。方法 原位肝癌模型小鼠切除肿瘤后建成肝癌切除术后小鼠模型 3 0只 ,随机分为 2组 :对照组隔日皮下注射 3 %酒精溶剂 ;TNP 470组隔日皮下注射TNP 470 ( 3 0mg/kg) ;用药至小鼠死亡。检测小鼠存活时间、各组复发率、复发瘤体积、处理前后腹围。 结果 TNP 470组较对照组生存时间明显延长 (P <0 0 5 ) ;TNP 470组较对照组复发率明显减少 ,复发瘤体积亦减小 (P <0 0 5 ) ;TNP 470组较对照组小鼠腹围明显减少 (P <0 0 5 )。结论 TNP

Objective: To evaluate whether TNP-470 could prevent the recurrence and metastasis of the KM mice bearing hepatocellular carcinoma. Methods: The tumor was resected to construct the model of postoperative mice, thirty of which were randomized into 2 groups: control (3% ethanol, sc,qod), TNP-470 (30 mg/kg, sc, qod) and detect the survival time; the ratio of recurrence, the longest and perpendicular dimension (a, b) of the recurrent tumor, the pre-treatment and post-treatment abdomen circumference of the mice. Results: the survival time of the TNP-470 group was longer than the control group(P<0.05); the ratio of recurrence and the volume of the recurrent tumor of the TNP-470 group was lower than the control group(P<0.05); the abdomen circumference of the TNP-470 group was shorter the control group (P<0.05). Conclusion: TNP-470 could prevent the recurrence and metastasis of the KM mice bearing hepatocellular carcinoma.