p53、c-myc、PCNA在大肠癌过度表达的临床意义

The Overexpression of p53, c-myc, PCNA in Colorectal Carcinoma

目的 :探讨 p5 3、c- m yc、PCNA在大肠癌组织中的过度表达及临床意义。方法 :采用免疫组化技术检测 PCNA、c- myc、p5 3在大肠癌、癌旁组织、正常大肠黏膜及大肠腺瘤性息肉中的表达。结果 :(1 ) p5 3、 c- m yc、PCNA在大肠癌组织中的表达明显高于癌旁组织、正常黏膜及腺瘤性息肉 (P <0 .0 5 ) ;(2 )伴淋巴结转移大肠癌组织 p5 3、 c- m yc及 PCNA的阳性表达率分别为 6 0 %、 80 %和 80 % ,与无淋巴结转移者比较有显著性差异 (P <0 .0 5 )。结论 :p5 3、 c- m yc及 PCNA蛋白在大肠癌转移过程中起重要作用 ,可作为预测大肠癌预后的生物学指标 ;检测 PCNA、c- myc及 p5

Objective:To investigate the overexpression and clinical singnifcance of p53, c myc, PCNA in colorectal carcinoma Methods:The expressions of p53, c myc and PCNA were detected by immunohistochemical method in 30 colorectal carcinoma, pericarcinomatous, normal colorectal mucosa, and 20 adenomatous polyps, respectively Results:(1) The overexpressions of p53, c myc and PCNA were markedly higher in colorectal carcinoma than in corresponding pericarcinomatous tissues, normal colorectal mucosa, and adenomatous polyps, respectively (P<0 05) (2) The positive rates of p53, c myc and PCNA in carcinoma with lymph node metastasis were 60%, 80% and 80%, respectively, and that without lymph node metastasis 10%, 20% and 5% respectively There were significant differences between the expressions of p53, c myc and PCNA in colorectal carcinoma with and without lymph node metastasis (P<0 05) Conclusion:p53, c myc and PCNA are correlated with progression and metastasis of colorectal carcinoma, and could be used as a helpful marker for predicting the metastastic potential and the prognosis of colorectal carcinoma.