血清CEA检测对大肠癌术后复发的早期诊断价值

Value of Early Diagnosis of Recurrence after Operations on Colorectal Carcinoma Through Serum CEA

目的 :探讨血清 ECA对大肠癌术后复发的早期诊断价值。方法 :用电化学发光法定量检测 1 4 8例大肠癌患者术前及术后血清 CEA值 ,并半年至 3年随访观察。结果 :经随访及化验检查证实 36例术后转移、复发。复发组有 2 6例术后 CEA值持续增高 ;6例术后 CEA值 1个月内下降至正常 ,1个月后再次增高 ;4例术后 CEA值持续正常 ,CEA阳性检出率为88.9%。 1 1 2例未复发组中术后 96例 CEA值在 1个月内降至正常 ,其后不增高 ;1 6例半年内 CEA增高 ,CEA阳性检出率为 1 4 .3%。复发组与未复发组 CEA阳性检出率有明显差异 (P <0 .0 5 ) ,有统计学意义。结论 :大肠癌术后血清 CEA值维持高水平 ,提示肿瘤转移、复发。术后动态监测血清 CEA 。

Objective:To study the value of early diagnosis of recurrence after operations on colorectal carcinoma through serum CEA.Methods:To measure serum CEA of 148 cases of colorectal carcinoma before and after operation by electrical chemistry lighting method, And the cases were through followed up from 6 mouths to 3 years.Results:36 cases showed recurrence in the followed up and examination.CEA of 26 cases remained high after operation in recurrences; 6 cases were reduced to normal in one mouth; the CEA were higher once again after one mouth; 4 cases were normal, the positive rate of serum CEA was 88 9%.CEA of 96 cases after operation were reduced to normal in one mouth of 112 cases of unrecurrences; 16 cases were higher in 6 mouths; the positive rate of serum CEA was 14 3%。The positive rate of recurrences was much difference from those without recurrences(P<0 05).Conclusion:The higher level of serum CEA suggested recurrence of carcinoma before after operations of colorectal carcinoma.Measurement serum CEA is of value in early diagnosis of recurrence after operations of colorectal carcinoma.