利用圆形分布的统计方法分析急性脑梗死患者死亡时间昼夜节律特点

Circadian variation rhythm of cerebral infarction death

目的 回顾性分析 6 4例急性脑梗死患者的死亡时间 ,探讨脑梗死患者死亡时间的昼夜节律变化的特点和规律。方法 分析 6 4例死亡病例的临床资料 ,重点分析死亡时间 ,利用圆形分布的统计方法 ,计算出死亡高峰时刻和 1天 2 4小时内 95 %的死亡时间集中时段。结果 急性脑梗死患者的死亡高峰时刻为 0 5 :5 9:31,1天 2 4小时内95 %的死亡时间发生在 0 1:0 4 :2 3～ 10 :5 4 :39。结论 急性脑梗死患者的死亡时间有一定的昼夜节律分布的特点 ,清晨通常为死亡的高峰时段 ,与机体血栓性病理状态恶化或血压的昼夜波动有关。工作中应注意加强夜间和凌晨患者的管理和监测 ,必要时改变投药时间 ,最大限度地减少死亡率。

Objective To analyze time of death in 64 cases of ischemic stroke patients retrospectively,and find out circadian rhythm of ischemic stroke death and hopefully can provide helpful information for clinical practice.Methods The time of death in 64 cases was analyzed by mathematical statistics.And the peak time of death and the period of 95% dead cases in 24 hours daily were calculated.Results The peak time of infarction death was at 5:59:31,the duration of 95% dead patients in 24 hours between 1:04:23 to 10:54:39.Conclusion Circadian rhythm has been noticed in cerebral infarction death in this study.The risky peak time of death in stroke patients always occurs in the early morning.However,neurologists should consider both individual variation and medical intervention for the individual patient to evaluate the time of death.Meanwhile,clinical staff should pay more attention to monitor stroke patients in the early morning and modify some certain medical remedies if necessary.