60例帕金森病患者抑郁及其相关因素的研究

Studies on relationship between depression and correlated factors in Parkinson′s disease

目的 研究帕金森病 (PD)患者的抑郁症状及其相关因素。方法 采用汉密尔顿抑郁量表 (HAMD)与简易精神状态检查量表 (MMSE)调查 6 0例PD患者的抑郁状态及认知功能。结果 病程 >5年者抑郁发生率与病程≤ 5年者抑郁发生率间差异有显著性意义 (P <0 0 1) ;Hoehn-YahrⅠ、Ⅱ期患者抑郁发生率与Ⅲ期以上患者抑郁发生率间差异有显著性意义 (P <0 0 1) ;抑郁患者MMSE得分与无抑郁者间差异有显著性意义 (P <0 0 1)。结论 PD患者有较高的抑郁发生率 ,与PD病程、病情分期。

Objective To study the depression and correlated factors of patents with Parkinson′s disease (PD).Methods 60 patients′ depression and cognitive ability were assessed by Hamilton Depression Rating Scale(HAMD) and Mini-Mental State Examination(MMSE).Results Incidence of depression in PD patients(46 7%)was higher than that of controls (7 5%).There was significant difference between the occurrence of depression in the PD patients whose duration were over 5 years and below 5 years.There was significant difference between depression patients inⅠ,Ⅱ stage of Hoehn-Yahr and ones over Ⅲ stage (P<0 01);the scores of MMSE in depression patients were lower than those of no depression(P<0 001).Conclusion There is high incidence of depression in PD patients.The severity degree of depression is associated with duration,course of disease and cognitive function.