阻塞性睡眠呼吸暂停综合征并高血压患者血清尾加压素Ⅱ水平及其病理学意义

UrotensinⅡ levels of the serums in obstructive sleep apnea syndrome patients with hypertension and the pathological significance

目的 探讨尾加压素Ⅱ在阻塞性睡眠呼吸暂停综合征并高血压发生、发展中的病理学意义。方法 选择阻塞性睡眠呼吸暂停综合征并高血压患者 2 6例 (实验组 )和正常人 2 6例 (对照组 ) ,用斑点蛋白印迹法测定其血清尾加压素Ⅱ水平 ,通过薄层扫描技术对数据进行半定量分析。结果 实验组血清尾加压素Ⅱ的光密度值为 ( 0 2 0 1±0 0 5 6 ) ,对照组为 ( 0 0 5 9± 0 0 2 2 ) ,两组间差别有显著性意义 (t =9 398,P <0 0 0 1)。结论 尾加压素Ⅱ的增高可能是阻塞性睡眠呼吸暂停综合征导致高血压发生、发展的重要因素 ,或为阻塞性睡眠呼吸暂停综合征并高血压的重要病理改变之一。

Objective Study on correlation of Urotensin Ⅱ(UⅡ) in serum to obstructive sleep apnea syndrome(OSAS)patients with hypertension.Methods The samples were collected from clinical OSAS with hypertension serum of 26 samples and 26 normal samples from health volunteers.Urotensin Ⅱ levels of the serums has been detected with Dot-Western blot,and compared between OSAS with hypertension patients and health persons with thin layer scanner and statistics treatment for semi-quantum analysis.Results Urotensin Ⅱ level of OSAS with hypertension serum(0 201±0 056A)is higher than the normal control (0 059±0 022 A)significantly(P<0 001).Conclusion Increase of Urotensin Ⅱ may be a kind of OSAS with hypertension developing cauaes or one of important pathological symptoms.