针刺百会、大椎对拟血管性痴呆大鼠GSH-PX、CAT的影响

The Influence of Needling Baihui and Dazhui on GSH-PX and CAT in A Rat Model of Vascular Dementia

目的 研究针刺百会、大椎穴对拟血管性痴呆 ( VD)大鼠的学习记忆行为及谷胱甘肽过氧化物酶 ( GSH-PX)、过氧化氢酶 ( CAT)的影响。方法 选用纯系 Wistar老年大鼠 36只 ,随机分为假手术组、模型组、针刺组和西药组 ,每组分别为 9只。采用 2 -血管阻断法制成 VD大鼠模型 ,共治疗 30日 ,治疗后以大鼠穿梭箱实验成绩检测学习记忆行为情况 ,并检测脑内 GSH- PX及 CAT的活力。结果 针刺 VD大鼠的百会大椎穴 ,可明显减少 VD大鼠在穿梭箱实验中的电击次数和电击时间 ,脑内 GSH- PX及 CAT活力增强。结论 针刺百会 ,大椎穴能提高 VD大鼠的学习记忆能力 ,并能改善自由基的代谢。

Purpose To investigate the influence of needling Baihui and Dazhui on learning, memory, glutathion peroxidase (GSH PX) and catalase (CAT) in a rat model of vascular dementia (VD). Methods Thirty six Wester rats were randomly divided into sham operation, model, acupuncture and Western medicine groups, 9 rats each group. A rat VD model was made by vessel occlusion and treated for 30 days. Rat's learning ability and memory were tested with a rat running box and intracerebral activity of GSH PX and CAT was determined. Results Needling points Baihui and Dazhui markedly decreased the number and time of electric shock to a VD rat in a running box experiment and increased the activity of GSH PX and CAT. Conclusion Needling points Baihui and Dazhui can improve learning ability and memory, and free radical metabolism in VD rats.