表皮生长因子(EGF)水平在慢性肝病中的动态变化及意义

Changes in serum level of epidermal growth factor in patients with chronic hepatitis and their significance

目的观察慢性肝炎肝硬化患者血清表皮生长因子(EGF)及甘草酸二胺注射液治疗前后血清EGF含量变化。方法 52例肝病患者分为3组。其中急性肝炎15例,慢性肝炎23例,肝炎后肝硬化14例,正常对照30例。EGF检测采用放射免疫分析方法。结果急性肝炎组、慢性肝炎组、肝炎后肝硬化组患者血清EGF水平与对照组相比具有显著性差异(P<O.01),且在药物治疗前后其水平具有显著性差异,治疗后EGF水平明显低于治疗前(P<0.01)。相关性分析表明,肝功能中丙氨酸氨基转移酶与EGF呈正相关。讨论 EGF可作为衡量肝脏炎症状况的参考指标。动态观察EGF水平对了解肝脏炎症及肝纤维化状况、疗效判断具有重要的参考价值。

To observe the changes in serum level of epidermal growth factor (EGF) in patients with chronic hepatitis and liver cirrhosis after treatment. Methods Serum level of EGF were determined with radioimmunoas- say in 52 patients including 15 with acute hepatitis, 23 with chronic hepatitis and 14 with hepatitis and liver cirrhosis and 30 healthy individuals. Results There was significant difference in serum level of EGF between the patients and normal controls ( P<0.01 ). In the 52 patients, the serum level of EGF was significantly lower after than before the treatment. The level of serum EGF was positively correlated to ALT level. Conclusions Serum level of EGF can be used as an index for assessment of the severity of liver inflammation and fibrosis. Meanwhile, it may be used to observe the therapeutic ef- ficacy.