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突触蛋白与神经系统疾病 被引量：1

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摘要 突触蛋白是一组与突触相关的具有神经元特异性的磷酸蛋白,突触蛋白在调节神经递质的释放和神经元的早期发育、再生等方面起着重要的作用。脑缺血缺氧、Alzheimer病、朊蛋白病和癫痫等神经系统疾病均存在突触蛋白表达的改变,研究突触蛋白表达的改变是研究这些神经系统疾病的发病机制、病理及生理改变的重要手段。
作者 梁燕玲 张苏明
机构地区 华中科技大学同济医学院附属同济医院神经内科
出处 《国外医学（神经病学．神经外科学分册）》 2004年第1期94-97,共4页 Foreign Medical Sciences（Section On Neurology & Neurosurgery）
基金 国家自然科学基金(30070825)
关键词 突触蛋白 神经系统疾病 神经元 发病机制 磷酸蛋白 脑缺氧缺血
分类号 R741 [医药卫生—神经病学与精神病学]
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参考文献20

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同被引文献33

  • 1梁燕玲,张苏明,许康.短暂脑缺血再灌流后大鼠突触蛋白-I的表达及其磷酸化水平[J].中风与神经疾病杂志,2004,21(3):196-198. 被引量：3
  • 2Iwakuma M,Anzai T,Kobayashi S,et al.Antisense in vivo knockdowm of synaptotagmin I and synapsin I by HVJ-liposome mediated gene transfer modulates ischemic injury of hippocampus in opposing ways.Neurosci Res2003;45(3):285-96.
  • 3Hilfiker S,Pierbone VA,Czzerinik AJ,et al.Synapsins as regulators of neurotransmitter release.Philos Trans R Soc Lond B Biol Sci 1999;354(1381):269-79.
  • 4Roman GC.Vascular dementia may be the most common form of dementia in the elderly.J Neurol Sci 2002;203-204(15):7-10.
  • 5Ford GA,Bryant CA,Mangoni AA,et al.Stroke,dementia,and drug delivery.Br J Clin Pharmacol 2004;57(1):15-26.
  • 6Masliah E.Recent advances in the understanding of the role of synaptic proteins in Alzheimer's Disease and other neurodegenerative disorders.J Alzheimer's Disease 2001:3:121-9.
  • 7Kovalenko TM,Osadchenko IO,Smozhanyk KH,et al.Structural orgamization of CA1 zone in the hippocampus of rats in the experimental brain ischemia.Fiziol ZH 2004:50(2):86-93.
  • 8Martone ME,jones YZ,Young SJ et al.Modification of postsynaptic densities after transient cerebral ischemia:a quantitative and three-dimensional ultrastructural study.J Neurosci 1999;19(6):1988-97.
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  • 10Remondes M,Schuman EM.Molecular mechanisms contributing to long-lasting synaptic plasticity at the temporoammonic-CA1 synapse.Learn Mem 2003;10(4):247-52.

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国外医学（神经病学．神经外科学分册）
2004年 第1期

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