前列地尔治疗重度黄疸型病毒性肝炎的临床疗效观察

Observation on the Clinical Effect of Alprostadil Injection in Patients with Severe Icterohepatitis

目的 :探讨前列地尔对重度黄疸肝炎的疗效。方法 :将 6 4例重度黄疸肝炎患者随机分为两组 ,前列地尔组 33例 ,对照组 31例。在促肝细胞生长素 12 0～ 2 0 0mg静脉点滴的基础上 ,治疗组加用前列地尔注射液 10～ 2 0 μg ,对照组加用茵栀黄注射液 30～ 4 0mL治疗 ,两组药物均溶于 5 %葡萄糖液 5 0 0mL中静滴 ,每日 1次 ,疗程均为 4周。结果 :治疗组对重度黄疸肝炎的疗效优于对照组 (P <0 0 5 ) ,其血清胆红素的降低显著优于对照组 (P <0 0 0 1) ,ALT、PTA下降均低于对照组 (P <0 0 5 )。结论 :前列地尔对重度黄疸肝炎有一定疗效。

Objective:To study the effect of alprostadil injection on severe icterohepatitis.Methods:64 patients with severe icterohepatitis were divided into two groups at random. There were 33 patients in the treated group and 31 patients in the control group .On the basis of using hepatocyte growth-promoting factors,the treated group was added with alprotadil injection 10～20μg and the control group with Yin-Zhi-Huang injection 30～40mL for 4 weeks,both in 5% glucosum injection 500mL,intravenous instillation once a day.Results:The curative effect of the treated group was much better than that of the control group(P<0.05).The total serum bilirubin(SB), ALT and PTA in the treated group were signifircantly lower than that of the control group(P<0.001～0.05).Conclusion:It is effective that using Alprostadil injection to treat the severe icterohepatitis.