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B12基因在小鼠部分肝切除后的表达差异分析 被引量：3

Differential Expression Analysis of B12 GeneAfter Mouse Partial Hepatectomy
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摘要 B12是一种受TNF α诱导的蛋白.利用肝脏部分切除小鼠模型以及核酸酶保护反应研究了B12基因在肝脏部分切除后不同时间的表达差异,发现在受损后28h,B12的表达开始增强,到36h表达一直呈上升趋势,推测该基因可能与肝脏修复过程中DNA的复制有关,为B12基因的进一步的功能研究提供了理论基础. B12 is a sort of protein induced by TNF-α. Used mouse partial hepatectomy(PHx) model and ribonuclease protection assay(RPA) to study the expression of B12 after the surgical removal of the liver at different recovery timepoints.The results showed that 28 h after PHx, the expression of B12 began to increase,and the trend of increasing prolonged to 36 h after PHx.These suggest that B12 might be involved in DNA replication in liver regeneration and provide a basis for further functional studies of B12.
作者 熊熙文 刘鑫 胡小晓 蒋小云 刘云海 张健
机构地区 湖南师范大学生命科学学院基因敲除与转基因动物研究室 南华大学生命科学与技术学院实验动物学部
出处 《湖南师范大学自然科学学报》 EI CAS 北大核心 2004年第1期71-74,共4页 Journal of Natural Science of Hunan Normal University
基金 教育部重点课题 湖南省教育厅重点课题
关键词 B12基因 小鼠 部分肝切除 表达差异 核酸酶保护反应 肝脏修复 B12 gene mouse partial hepatectomy(PHx) ribonuclease protection assay(RPA)
分类号 R333.4 [医药卫生—人体生理学] R-332 [医药卫生]
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参考文献12

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共引文献71

同被引文献18

  • 1胡小晓,熊熙文,周建林,张健.小鼠肿瘤致死因子α诱导的TNFAIP1蛋白与DNA聚合酶δ亚单位的相互作用[J].湖南师范大学自然科学学报,2004,27(3):70-74. 被引量：2
  • 2Xiao-WeiLiu,Fang-GenLu,Guang-SenZhang,Xiao-PingWu,YuYou,Chun-HuiOuyang,Dong-YeYang.Proteomics to display tissue repair opposing injury response to LPS-induced liver injury[J].World Journal of Gastroenterology,2004,10(18):2701-2705. 被引量：5
  • 3杨利平,周爱冬,李红,张文峰,吴艳阳,张健,韩梅.人TNFAIP1基因在常见细胞系中的表达[J].遗传,2006,28(8):918-922. 被引量：7
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引证文献3

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湖南师范大学自然科学学报
2004年 第1期

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