小剂量乌拉地尔治疗伴血压高的急性左心衰临床观察

Clinical Observation of the Treatment of Acute Left Heart Failure with High Blood Pressure by Low Dosage of Urapidil

目的:评估小剂量乌拉地尔治疗伴血压高的急性左心衰的疗效及可行性。方法:78例伴血压高的急性左心衰,分成治疗(A)组和对照(B)组,A组用常规抗心衰药物加乌拉地尔25 mg;加入100 mL液体中,以100-200μg/min静滴治疗,B组单用常规抗心衰药物治疗。结果:A组在疗效方面优于B组(P<0.05),总有效率95.0％。用药5 min后血压即明显控制,20-30 min达到高峰,并在此后保持稳定,SBP、DBP及HR在用药后各时间段与用药前相比有显著下降(P<0.05)。结论:小剂量乌拉地尔治疗伴血压高的急性左心衰起效快,疗效显著,副作用小,可作为治疗伴血压高的急性左心衰的常规用药。

Objective: To evaluate the efficiency and feasibility of low dosage urapidil treating acute left heart failure (ALHF) with high blood pressure. Methods: 78 cases of ALHF with high blood pressure were divided into the therapy group (Group A) and the control group (Groups B). The patients in Group A were given low dosage of urapidil (25 mg+100 mL liquid, 100-200 μg/min) during the conventional treatment. Observing the changes of blood pressure and heart rate at the time before injection and 5 min, 10 min, 20 min, 30 min, 60 min after first administration. While the patients in group B were only give the conventional treatment. Results: The effect of reducing blood pressure and slowing down heart rate in Group A is better than in group B (P<0.05). The total effective rate of urapidil in the Group A is 95.0%. In Group A, 5 min after injection, blood pressure immediately dropped and reached the maximal extent 20-30 min, and remain at the stable level during the behind time, and heart rate dropped simultaneously. The efficiency of Group A was higher than Group B (P<0.05). Conclusion: Using low dosage of urapidil based on conventional therapy in the patients with ALHF and high blood pressure, the initiation of efficacy is rapid, the effect is satisfactory and side-effect is little. Low dosage of urapidil is an ideal choice in the treatment of ALHF with high blood pressure.