T淋巴细胞与胶原诱导性关节炎

T Lymphocyte and Collagen-induced Arthritis

胶原诱导性关节炎是应用较广泛的人类风湿性关节炎动物模型 ,二者在发病机制及病理学改变上极为相似。近年来研究证实激活的某些T细胞在胶原诱导性关节炎的发病过程中起着重要作用 ,尤其在疾病的起始阶段 。

Collagen-induced arthritis (CIA) is a widely-used experimental animal model o f human rheumatoid arthritis(RA) which shares certain features with RA, such as in pathogenesis and pathology. Recent research demonstrates that some activated T cells are critical to the development of CIA, especially during the initial ph ase. All suggests that CIA is kind of dominant T cell-mediated autoimmune disea se.