摘要
目的:评价静脉高氧液疗法对电惊厥疗法治疗(electroconvulsive therapy,ECT)的认知功能损害的疗效,并对其作用机制加以探讨。方法:108例符合CCMD.Ⅲ抑郁发作诊断标准病例,被随机分ECT加高氧液治疗组和ECT治疗对照组,共进行6次治疗,ECT采用硫苯妥钠诱导麻醉下,右侧电极直流矩形波的有抽搐治疗,于治疗前后分别测验临床记忆量及反应时。 结果:高氧液治疗组的认知功能较对照组的损伤轻,指向记忆商(15.77±6.95)及人像特点回忆商(13.43±6.78)分值较对照组增高(P<0.01)。反应时(578.90±185.00)显著缩短(P<0.01)。 结论:静脉高氧液在ECT治疗中具有脑保护作用,改善ECT治疗引起的认知功能损害。
AIM: To evaluate the efficacy of hyperxia liquid on cognitive impairment of patients treated with electroconvulsive therapy (ECT), and to explore its mechanisms of action.
METHODS: One hundred and eight patients met with CCMD-Ⅲ criteria for major depression were randomly divided into two groups: ECT combined with hyperxia liquid treatment group, ECT treatment control group (control group). Every patient were treated with a right unilateral, brief pulse, square-wave stimulus, dose titration ECT. Before and after course of 6 times, clinical memory score and reaction time were tested.
RESULTS: In the treatment group, the cognitive impairment was lighter than that in the control group, the tests of target memory(15. 77 ±6. 95), image characteristic recall(13. 43±6. 78) were higher( P < 0. 01), and the reaction time(578. 90 ± 185. 00) was significant lower( P < 0. 01) than those in the control group.
CONCLUSION: Hyperxia liquid has the protective effect on brain in the treatment of ECT, and it can improve the cognitive impairment caused by ECT treatment.
出处
《中国临床康复》
CSCD
2004年第9期1630-1631,共2页
Chinese Journal of Clinical Rehabilitation
