急性中度低压缺氧对飞行员血浆血管紧张素Ⅱ及肾上腺髓质素含量的影响(英文)

Effects of acute moderate hypobaric hypoxia on plasma angiotension n and adrenomedullin in pilots

目的:探讨急性中度低压缺氧对飞行员血浆血管紧张素Ⅱ(AⅡ)及肾上腺髓质素(ADM)含量的影响。 方法:用放射免疫法测定了16名健康男性歼击机飞行员缺氧前、急性中度低压缺氧后即刻及到达地面6h后的血浆AⅡ及ADM的含量,并以16名健康男性地面人员相应时间的测定作对照。 结果:①缺氧前飞行员的血浆AⅡ及ADM含量[(72.56±4.69),(48.81±3.68)ng/L]与对照组[(69.60±4.58),(46.43±3.45)ng/L]比较,差异无显著性意义(P>0.05)。②急性中度低压缺氧后即刻,飞行员的血浆AⅡ及ADM含量[(77.68±5.18),(52.72±4.13)ng/L]较缺氧前明显增加(P<0.05),缺氧结束后6h[(74.03±4.88),(48.72±3.64)ng/L]恢复到缺氧前水平。 结论:急性中度低压缺氧可导致飞行员血浆AⅡ及ADM的含量增加,这种影响是一过性的。

AIM:To explore the effects of acute moderate hypobaric hypoxia (AMHH) on plasma angiotension Ⅱ(AⅡ) and adreomedullin(ADM) content in pilots.METHODS:The concentrations of plasma AⅡ and ADM were measured by radioimmunoassay in 16 healthy male pilots before hypoxia,at the moment of AMHH and 6 hours after returning to the ground.A total of 16 healthy male ground crews were set as control group,and their plasma AⅡ and ADM contents were assayed at corresponding time. RESULTS:(1)There was no significant difference in plasma AⅡ and ADM contents of pilot group[ (72.56±4.69),(48.81±3.68) ng/L] and the control groupf (69.60±4.58),(46.43±3.45) ng/L] (P>0.05).(2) Plasma AⅡ and ADM contents immediately after AMHH in the pilot group [(77.68±5.18),(52.72±4.13) ng/L]was significantly higher than that before AMHH ( P < 0.05),then it returned to normal level 6 hours after hypoxia[(74.03±4.88),(48.72±3.64) ng/L]. CONCLUSION:AMHH can induce temporary increase of plasma A Ⅱ and ADM in pilots.