摘要
在培养的人心肌细胞上研究了黄芪、人参抗Cox B-3及Echo-19病毒的作用及诱生干扰素的效应,结果表明两种药物分别作用于人心肌细胞48小时及感染病毒的心肌细胞在含药物的营养液中培养均可降低细胞对两种病毒感染的敏感性,此作用与药物诱导心肌细胞产生IFN有关。
In this study, we assayed the antiviral effect of AM and RG againstCoxsackie B-3 and Echo-19 viruses and the influence of these two drugs onthe susceptibility of human heart cells to viral infection. Results of the studyrevealed the following: human heart cells, depleted endothelial cells and fibro-blasts by 2 hours adsorption, grown up to monolayer by 9th-10th day, survi-ved more than one month. AM and RG have no direct inactivating effect onCox B-3 and Echo-19 viruses. Heart cells pretreated with AM and RG for48 hours before infection and treated with the drugs after viral infection re-sulted in lowered susceptibility of heart cells to viral infection. The antiviralactivity of the cells induced by AM or RG may be related to its effect to in-(duce and enhance IFN production.
出处
《中国病毒学》
CSCD
1992年第1期36-42,共7页
Virologica Sinica
基金
本文为国家自然科学基金资助课题
关键词
黄芪
人参
人心肌细胞
抗病毒作用
Astragalus membranaceus
Radix ginseng
Human myocardiall cell
Cox B-3 virus
Echo 19 virus
