摘要
本实验应用HSV-Z诱导小鼠宫颈癌的动物模型,发现人精浆或厌氧菌培养液只引起宫颈上皮轻度增生,二者混合(SB)不仅可致宫颈癌(11.5％),而且使HSV-2诱癌率从23.1％提高到50％,同时发现SB具有抑制机体细胞免疫功能的作用,抑制ConA刺激的淋巴细胞转化及NK细胞的活性。上述结果提示SB具有促癌作用,因而也讨论了SB促癌的可能机制。
Co-carcinogensis of seminal plasma(S), culture fluid of anaerobic bacteria(B) and Herpes Simplex Virus type 2(HSV-2) induced cervical carcinoma inmice were studied. The results showed that there were slight displasia insingle seminal Plasma(S) group or culture fluid of anaerobic bacteria group,cervical carcinoma could be induced by SB with an induction rate of 11.5%;23.1% of the carcinoma rate in HSV-2 group and 50.0% of the rate in HSV-2+SB group. The experimental results indicated that SB was both carcino-genic and tumor promoting. The possible mechanism of the action of SB wasdiscussed.
出处
《中国病毒学》
CSCD
1992年第1期11-15,共5页
Virologica Sinica
基金
国家自然科学基金资助项目
关键词
人精液
宫颈癌
厌氧菌
HSV-2
Seminal plasma
Anaerobic Bacteria
Cellular Immune
Cervical Carcinoma
