抗—HBe阳性慢性乙肝临床研究

A Clinical Study on Anti--HBe Positive Chronic Hepatitis B

报告34例抗-HRe阳性慢性乙型肝炎(CHB),占同期住院抗-HBe阳性者的38％。这些患者于3—9年内肝炎再活动2—4次,累计80次。肝炎再活动时的临床表现及肝功损害与同期住院的HBeAg阳性CHB相似,但抗-HBe阳性CHB者肝硬化及肝癌发生比例显著高于HBeAg阳性者(P<0.05)。血清乙肝病毒标志(HBVM)检测发现,80次肝炎再活动中,38次(47.5％)有HBV活跃复制,提示HBV活跃复制是部分抗-HBe阳性CHB肝炎再活动的根本原因,另一部要考虑是其它肝炎病毒重叠感染的结果。

We introduce 34 patients with anti-HBe Positive chronic hepatiti B (CHB). They accounted for 38% of all anti-HBe positive patients in the periodof the same time. There are 2-4 times reactivation in the period of 3-9 years(added up 80 times). During their reactivation of hepatits the clinical man-ifestation and degree of injured liver function are similar to HBeAg positivepatients in the same period. However, the ratio of occuring cirrhosis andhepatocarcinoma of anti-HBe positive CHB is significantly higher than that ofHBeAg positive CHB (P<0.05). Among serum hepatitis B virus marks detected in80 times of rerctivation. there are HBV active replication in 38 times (47.5%).The results showed that HBV active replication is a radical cause of the antiHBe positive CHB reactivation. The other cases should be considered as over-lapping infection of other type hepatitis virus.