咪达唑仑在全麻诱导中的应用

Application of Midazolam During Induced Anesthesia

目的 观察咪达唑仑用于全麻诱导的效果。方法 6 0例全麻患者随机分为 2组。Ⅰ组采用咪达唑仑 0 3mg/kg静脉诱导 ;Ⅱ组采用硫喷妥钠 5mg/kg静脉诱导。分别记录患者眼睑反射消失时间及诱导前后MAP和HR。结果 眼睑反射消失Ⅱ组快于Ⅰ组 ,但无统计学差异 (P >0 0 5 ) ,诱导后MAP明显降低 (Ⅰ组P >0 0 5 ,Ⅱ组P <0 0 1 ) ,HR增快 (P <0 0 1 ) ;插管过程中 2组血压均明显升高 (P <0 0 1 ) ,HR也明显增快 (P <0 0 1 ) ;插管后 5min 2组MAP、HR均基本恢复至诱导前水平。结论 咪达唑仑用于全麻诱导效果满意 ,对循环抑制轻于硫喷妥钠 ,尤其适用于合并心血管疾病。

Objective To observe the effect of midazolam during induced anesthesia. Methods 60 cases of general anesthesia were divided into two groups. A group was induced with 0.3 mg/kg intravenously. B group was induced with thiopental. The eyelid reflection, MAP and HR were recoded separately. Results The eyelid reflection in group B disappeared faster than that in group A without significance. After induced, MAP decreased obviously (P>0.05 in group A, P<0.01 in group B) and HR increased (P<0.01). During intubation the MAP and HR increased obviously and decreased and came back as before after 5 min of intubation. Conclusion The inducing with midazolam could reach satisfied effect during general anesthesia and better than thiopental for the patient combined with cardiovascular, senile and fragile patient.