洛索洛芬钠治疗膝骨关节炎的临床研究

Clinical observation of loxoprofen sodium in treatment of patients with knee osteoarthritis

目的:评价洛索洛芬钠片(乐松)治疗膝骨关节炎(OA)的疗效和安全性。方法:选取OA病人40例,每组20例,采用随机、开放、对照法,试验组:口服洛索洛芬钠片60mg,3次/d;对照组:口服布洛芬缓释胶囊300mg,2次/d。疗程为4周。分别观察治疗前后临床指标和炎性实验指标的变化及不良反应。结果:比较两组在治疗前后组内膝关节活动痛、15m行走时间、日常活动能力及病人综合评估等方面,均显示有显著性差异;而组间比较均无显著性差异。两组总有效率无显著性差异。结论:洛索洛芬钠对OA的疗效与布洛芬相当,且不良反应更轻。

Objective: To evaluate the efficacy and safety of loxoprofen sodium in treatment of patients with osteoarthritis (OA). Methods: The study was conducted in 40 patients of OA by a random, open and controlled method. All of them were in line with the criteria of American College of Rheumatology. They were divided to receive oral loxoprofen 60 mg tid or sustained release ibuprofen 300 mg bid for 4 weeks. Results: After 4 weeks treatment, all parameters including active pain of knee, time for walking 15 meters, ability of daily life and patientself-evaluation in patients with OA were significantly improved by both agents (ibuprofen and loxoprofen sodium) ,but there was no significant difference between the 2 medicine groups. Conclusion: Loxoprofen is as effective as ibuprofen in treatment of patients with OA,and has milder side effects.