高渗氯化钠对兔失血性休克时肾形态的影响——超微结构观察

Morphological effect of hypertonic sodium chloride on rabbit kidney with hypovolemic shock——ultrastractural observation

本文从超微结构水平描述了两种氯化钠溶液对休克肾的作用。结果说明,高渗氯化钠对休克肾的微血管、肾单位各部均有明显的保护作用,为临床应用提供某些形态学依据。

In the present experiments, the effect of hypertonic NaCl infusion on the renal ultrastructure in rabbits with hypovolemia was examined by electron microscopy. Rabbits were anasthetized with pentobarbital sodium and submitted to control bleeding and held at a mean arterial pressure of 40 mm Hg for 45 minutes. They were then given 6 ml/kg i. v. of 1) isotonic NaCl (300 mosm/L; 2) hypertonic NaCl (2400mosm/L). Only animals receiving hypertonic NaCl had immediate and permanent resto ration of mean arterial pressure and nearly intact ultrastructure of nephron. However, the animals with isotonic NaCl had an ischemic changes of nephron ultrastructure and unrestored mean arterial pressure.