侧脑室灌注CaCl_2对家兔内毒素性发热及其血浆、脑脊液中cAMP含量的影响

The effects of perfusing the lateral cerebroventricle with 40mM CaCl_2 on the febrile response and cAMP concentrations in the plasma and cerebrospinal fluid during endotoxic fever in rabbits

本研究选用新西兰白兔40只,观察侧脑室灌注CaCl_2改变脑组织固有Na^+/Ca^(++)比值时对家兔内毒素性发热及其血浆、脑脊液cAMP含量的影响。结果发现:侧脑室灌注CaCl_2可明显抑制家兔静脉注射内毒素引起的体温升高,同时也明显抑制了脑脊液cAMP含量的增多,由此推论Na^+/Ca^(++)比值升高导致cAMP含量增多,可能是内毒素性发热发病学的重要中枢环节。

The effects of perfusing the lateral cerebroventricle with CaCl_2 on the febrile response and cAMP concentrations of the plasma and cerebrospinal fluid(CSF) during endotoxic fever were observed in forty experimental rabbits. The results showed that the increase of the body temperature and cAMP concentration in CSF induced by endotoxin were significantly inhibited by perfusing the lateral cerebroventricle with CaCl_2. The authors inferred that the increase of Na^+/Ca^(++) ratio led to the increase of cAMP concentration in the hypothalamus may act as an important central febrile link in endotoxic fever. In addition, cAMP may have no relation with the mechan ism that the decrease of Na^+/Ca_(++) ratio in the hypothalamus can cause the fall of the normal body temperature in rabbits.