毁损家兔腰段脊髓对电针“长强穴”降热效应的影响

Effect of needling “Chang Qiang Point” on the febrifugal and analysis its mechanism after damaging lumbar spinal cord of febrile rabbits

毁损家兔腰段脊髓后观察电针“长强穴”降热效应的影响。实验结果表明;电针发热家兔“长强穴”,对发热效应具有显著的抑制作用。60分钟时△T℃为0.23±0.07;TRI_4为0.61±0.03,与LP组比较(△T℃为0.68±0.06;TRI_4为2.10±0.05)分别具有高度显著性(P<0.01)或显著性(P<0.05)。此时,脑脊液中cAMP含量,在60分钟时(为20.50±1.87nmol/L)与LP组比较(28.59±2.77nmol/L),具有高度显著性差异(P<0.01)。但在毁损腰段脊髓后,再电针发热家兔“长强穴”,其发热效应并未受到抑制,60分钟时△T℃为0.66±0.10;TRI_1为0.62,与LP组比较(△T℃为0.68±1.0;TRI_1为0.65)则无显著性差异(P>0.05)。州时,脑脊液中cAMP含量显著增加(27.28±2.12nmol/L),与LP组比较(28.59±2.27nmol/L)无显著性差异(P>0.05)。单纯腰段脊髓毁损对家兔体温,LP发热效应有一定影响,但对脑脊液中cAMP含量在60分钟无明显影响。由此,作者推论:电针“长强穴”的降热效应和机制,很可能是电针该部位时所引起的神经冲动,通过脊髓传入中枢神经系统,主要传入PO/AH区的神经元细胞,以某种方式导致cAMP生成减少,抑制“调定点”上移,故出现发热抑制效应。

In order to observe the febrifugal response of needling 'Chang Qiang Point', and analyse its mechanism lumbar spinal cord of rabbits were damaged in the expermental study. The experimental findings were as follows: 1. It was found that cAMP content in csf was striking increased, when leukocytic pyrogen fever of rabbits was significant. During needling 'Chang Qiang Point' of febrile rabbits, however, febrile response was markedly inhibited(at 60 min~ΔT℃ was 0.23±0.07 and TRI4 0.61±0.03). There was significant difference(P<0.01 and P<0.05), when two groups were compared, while cAMP content in csf (at 90 rain was 20.50±1.87 nmol/L) was apparently decreased as compared with LP group, there was obvious difference (P<0.01).2. After damaging lumbar spinal cord of febrile rabbits, the febrile response was notinhibited(at 60 rain~ΔT℃ was 0.66±0.10, TRI_1 0.62±0.10). During needing 'ChangQiang Point', the cAMP content in csf was significantly increased (27.28±2.12 nmol/L). As compared with LP group, there was no significant difference (P>0.05). 3. After damaging lumbar spinal cord of rabbits, there were certain change of rectal temperature and the febrile response, but it had no effect on cAMP content in csf. The authors infered that the impulses from 'Chang Qiang Point' transmiled Via spinal cord might be closely associated with reflex mechanism and the change of cAMP content might play an important role in the mechanism of febrifugal effect during needling 'Chang Qiang Point' in febrile rabbits.