双后肢枪弹伤早期血管活性肽类物质变化的实验研究

Experimental study on the changes of vasoactive peptides after missile injuries of extremities

对双后肢遭受高速枪弹伤后早期狗血浆、脑脊髓液(CSF)及脑匀浆中血管活性肠肽(VIP)、血管紧张素Ⅰ(AⅠ)和血管紧张素Ⅱ(AⅡ)等肽类物质进行动态监测。发现:(1)血浆VIP、AⅠ和AⅡ含量伤后30min开始升高,至伤后4h仍持续显著升高,其伤后最高值分别为伤前值的2.9、11.5及4.9倍;(2)CSF中VIP含量在伤后4 h显著升高,但AⅠ和AⅡ有一过性降低;(3)脑匀浆VIP和AⅡ的含量与它们在CSF中的变化基本一致。上述研究结果的意义值得进一步探索。

The dynamic changes about vasoactive intestinal peptide (VIP), angiotension Ⅰ (AⅠ)and angiotension Ⅱ (A Ⅱ)concentrations in plasma, cerebral spinal fluid (CSF) and brain extracts were studied in the experimental high-velocity missile wound models, which were produced on both hind legs of dogs. The findings were as follows: (1) Plasma VIP, AⅠ and AⅡ concentrations started to increase from 30 rain after the wound and the elevation had been continuing at 4 h after the wound. Their highest points of post-trauma were 2,9, 11.5 and 4.9 times as much as that of pre-trauma. (2) CSF VIP elevated at 4 h after the wound, but AⅠ and AⅡ concentrations reduced tempo tarily at 1 h and 2 h after the wound respectively. (3) The changes of VIP, AⅡ concentrations in the brain extracts tented to be consistent with that of the CSF. The signifcance and machanism of these changes of VIP and AⅡ concentration remain to be clarified.