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t(12;21)儿童急性淋巴细胞白血病发病机制的研究进展 被引量：3

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摘要 t(12;21)(p13;q22)是儿童急性淋巴细胞白血病最常见的染色体易位,易位形成的TEL-AML1融合基因在白血病发病中起重要作用。TEL-AML1融合蛋白能募集N-CoR、roSin3和SMRT等核辅助抑制因子,与TEL蛋白形成异二聚体而干扰野生型TEL蛋白的功能,并与野生型AML1竞争AML1结合位点而起显著负性抑制作用。t(12;21)可能是致白血病的必要的初始遗传事件之一,其他细胞遗传学异常、尤其是未易位的TEL等位基因缺失,对疾病的发生、发展起着重要的促进作用。
作者 林冬 王建祥
机构地区 中国医学科学院中国协和医科大学血液学研究所血液病医院
出处 《国外医学（输血及血液学分册）》 2004年第2期137-140,共4页 Foreign Medical Sciences(Section of Blood Transfusion and Heanatology)
关键词 t(12 21) 儿童 急性淋巴细胞白血病 发病机制 研究进展
分类号 R733.7 [医药卫生—肿瘤]
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参考文献26

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同被引文献32

  • 1赵佳炜（综述）,王敏（审校）.MLL基因重排及其新伙伴基因的检出方法[J].国际输血及血液学杂志,2007,30(1):70-73. 被引量：1
  • 2Scherr M, et al. Specific inhibition of bcr - abl gene expression by small interfering RNA. Blood, 2003, 101 (4) :1566 -1569.
  • 3Chen J, et al. Stable expression of small interfering RNA sensitizes TEL - PDGFbetaR to inhibition with imatinib or rapamycin. J Clin Invest, 2004,113(12) :1784 - 1791.
  • 4Ptasznik A ,et al. Short interfering RNA (siRNA) targeting the Lyn ki- nase induces apoptosis in primary, and drug - resistant, BCR - ABL1 ( + ) leukemia cells. Nat Med, 2004,10(11) :1187 -1189.
  • 5Heidenreich O,et al. AMLI/MTG8 oncogene suppression by small interfering RNAs supports myeloid differentiation of t( 8 ;21 ) - positive leukemic cells. Blood, 2003,101 ( 8 ) : 3157 - 3163.
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  • 7M iyoshi H, et al. The t (8 ;21 ) translocation in acute myeloid leukemia results in production of an AML1 - MTG8 fusion transcript. Embo J, 1993,12(7) :2715 -2721.
  • 8Dunne J,et al. siRNA - mediated AML1/MTG8 depletion affects differentiation and proliferation- associated gene expression in t( 8 ;21 ) -positive cell lines and primary AML blasts. Oncogene, 2006,25 (45) :6067 - 6078.
  • 9Kasashima K,E Sakota, T Kozu. Discrimination of target by siRNA: designing of AML1 - MTG8 fusion mRNA - specific siRNA sequences. Biochimie, 2004,86(9 - 10) :713 -721.
  • 10Ziemin - van der Poel S,et al. Identification of a gene, MLL, that spans the breakpoint in 11 q23 translocations associated with human leukemias. Proc Natl Acad Sci U S A, 1991,88 (23) :10735 -10739.

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国外医学（输血及血液学分册）
2004年 第2期

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