咪达唑仑在呼吸功能减退患者行纤维支气管镜检查中作用观察

Observation of the effect of midazolam on breath subsidence patients in fibrobroscopy

目的 :观察呼吸功能减退患者使用咪达唑仑后 ,在纤支镜检中心率 ( HR)、血压和血氧饱和度 ( Sa O2 )的变化。方法 :A组 40例为呼吸功能显著减退患者 ;B组 ( 4 0例 )为对照组 ,两组镜检前 30 min以咪达唑仑 0 .0 4 mg/kg肌肉注射 ,于用药前 ,操作中及镜检结束时记录收缩压 ( SBP)、舒张压 ( DBP) ,平均动脉压 ( MAP)、HR和 Sa O2 。结果 :与基础值相比 ,镜检中两组 HR均有增快 ( P<0 .0 1或 0 .0 5 ) ,两组 SBP、DBP、MAP亦无显著性差异 ( P>0 .0 5 ) ,A组 Sa O2 的基础值低于 B组 ,镜检中 A组 Sa O2 显著下降 ( P<0 .0 1 )。结论 :对呼吸功能减退患者在纤支镜检查中使用咪达唑仑 ( 0 .0 4 mg/kg)是安全有效的 ,能减轻患者在镜检中的痛苦 。

Objective:To observe the changeDepartment of Respiratory Diseases, the People's Hospital,Taikang County of Henan Province(Taikang 461400) of heart rate (HR)、blood pressure(BP) and SaO 2 in fibrobrochoscopy after the subsidence patients have taken midazolam. Methods:Group A including 40 patients was the group of the notable breath subsidence patients and group B including 40 persons was the control group. Midazolam was added 30 minutes before fibrobrochoscopy by im(0.04 mg / kg) in both the two groups. Then SBP,DBP,MAP,HR and SaO 2 were observed before the use of medicine,during the operation and at the end of fibrobrochoscopy. Results:Compared with basic data ,the HR of the two groups in fibrobrochoscopy was both faster (P<0.01 or 0.05), and there were not great differences in the SBP DBP and MAP between the two groups. The basic data of SaO 2 went down remarkablely (P<0.01) in fibrobrochoscopy and was lower than that of group B. Conclusion:The use of midazolam(0.04mg/kg) is secure and effective. It can not only ease the pain of the patients in fibrobrochoscopy ,but also increase the conformance of the check.