CA_(125)、CA_(199)及CA_(153)联合检测对肺癌的诊断价值

Diagnostic significance of measuring CA_(125) ,CA_(199) and CA_(153) for patients with lung cancer

目的 :评价血清 CA12 5、CA199、CA153联合检测对肺癌诊断及分期的临床价值。方法 :用免疫放射分析法测定 72例不同类型及分期的肺癌患者 ,46例肺良性疾病患者及 38例健康体检者血清 CA12 5、CA199、CA153水平的变化。结果 :肺癌组血清 CA12 5、CA199、CA153水平均高于正常对照组及肺良性疾病患者 ,有显著性差异 ,且 TNM分期越晚 ,其水平越高。 3项肿瘤标志联合检测可提高敏感性及准确性。结论 :CA12 5、CA199、CA153联合检测可以为肺癌的诊断及分期提供有价值的实验室依据。

Objective: To evaluate the clinical value of measuring three tumor markers(CA 125 、CA 199 、CA 153 ) in the lung cancer diagnosis and different stages.Methods: The levels of the CA 125 , CA 199 and CA 153 in the serums which were from 72 cases of lung cancers, 46 benign lung diseases and 38 healthy subjects were measured with immunoradiometric assay(IRMA) and analyzed statistically. Results:The average levels of CA 125 , CA 199 and CA 153 of the lung cancer group were all higher than those of benign lung diseases and healthy subjects, and the differences were obvious statistically. The later the stage of TNM of lung cancer, the higher levels of 3 markers would be revealed. The sensitivity and the veracity of the measuring of all three tumor markers were higher than those of respective assay of all three tumor markers. Conclusion: The measuring of three tumor markers(CA 125 , CA 199 , CA 153 ) may provide valuable laboratory proof in the diagnosis and stages of lung cancers.