原发性骨质疏松症与肿瘤坏死因子α水平的关系研究

Tumor necrosis factor-a in aged patients with primary osteoporosis

目的 研究老年人原发性骨质疏松症与肿瘤坏死因子α(TNF-α)水平的变化。方法 选择老年性骨质疏松患者43例,采用放射免疫法测定血清肿瘤坏死因子α的水平,采用双能X线法测定患者的腰椎及股骨骨密度,根据骨密度值将病人分为骨质疏松组(22例)及非骨质疏松组(21例)。结果 血清TNF-α与老年人股骨颈、Ward氏三角及股骨总骨密度呈负相关;血清TNF-α在骨质疏松组明显高于非骨质疏松组,两者差异存在显著性。结论 TNF-α可促进破骨细胞的增殖、分化及成熟破骨细胞的活性,诱导成骨细胞的凋亡,从而抑制骨形成,增加骨吸收,最终导致骨质疏松。

Objective To study the relationship between the bone mineral density in aged primary osteo-porotic patients and serum TNF-α level. Methods Serum TNF-α level was assaged by radioimmunoassay and BMD was measured by dual energy X-ray absorptiometry(DEXA) .Results Sernm TNF-a level was negtively correlated with BMDs of femoral neck, Ward s triangle and total hip bone, and was significantly higher in aged primary os-teoporotic patients than that in non-osteoporotic patients. Conclusion TNF-α stimulates the proliferation and differentiation of osteoclasts, activates the mature osteoclasts, prevents bone formation, accelerates bone absorption, and at the end induces osteoporosis.