辅酶Q_(10)对异丙基肾上腺素心肌损伤电活动的保护作用

Protective effect of Co Q_(10) on the electrical activities of ISO-induced myocardial lesions

本实验在大鼠右心室乳头肌上观察辅酶 Q_(10)在预防异丙基肾上腺素(异丙肾)所致心肌损伤细胞电活动的影响。异丙肾可影响心肌细胞去极化和复极化过程,使 APA、OS 和 RP 降低、APD 延长、Vmax 下降;辅酶 Q_(10)可减轻异丙肾对心肌细胞的电效应,使 APD 缩短、特别是 APD_(50)的缩短尤为明显。实验结果表明:辅酶 Q_(10)对心肌的保护作用,可能与阻滞细胞膜慢通道、减少细胞内钙负荷有关。

Protective effect of Co Q_(10) on the myocardial electrical activities wasobserved on the papillary muscle cells of isoproterenol (ISO)-inducedmyocardial injury in rats.ISO decreased APA,OS,RP and Vmax,prolongedAPD;Co Q_(10) can reduce the electrical response of ISO on the myocardialcells.It shortened the APD,the APD_(50) especially obvious.The experimental results showed:Blocking slow channel decreasingcellular calcium load may be one of the important ways in the protectiveeffect of the Co Q_(10) on the myocardium.