多序列比对的两种新方法

Two novel methods for multiple sequence alignments

对两种用于多序列比对的新方法———T COFFEE和MAFFT进行了研究,结果表明:T COFFEE是迄今为止准确性最高的方法,但此方法速度较慢;而MAFFT则将FFT运用于比对中,使速度大大提高,并且与T COFFEE的准确程度相当.

The methods of T-COFFEE and MAFFT for multiple sequence alignments are studied. The results show that T-COFFEE provides alignments of the highest accuracy among the methods to date, but its rate is low. As for MAFFT, owing to the application of FFT, the CPU time is greatly reduced, and its accuracy is comparable to that of T-COFFEE.