噻唑烷二酮类药物与胰岛素抵抗

Thioazolidinediones and insulin resistance

目的:综述噻唑烷二酮类(TZDS)药物治疗胰岛素抵抗的作用机制、在Ⅱ型糖尿病中的作用、对胰岛素敏感性的影响、副作用和临床使用。方法:文献学方法。结果:噻唑烷二酮类(TZDS)药物通过多种机制提高了胰岛素抵抗及Ⅱ型糖尿病病人对胰岛素的敏感性,改善了患者的胰岛素抵抗状态。结论:噻唑烷二酮类(TZDS)药物具有很高的临床使用价值,但使用时应注意其所带来的不良反应。

Objective: To review the mechanisms of action of thiazolidinediones, clinical efficacy in patients with type 2 diabetes mellitus, effects on insulin sensitivity, side-effects and guideline for the clinical use of thiazolidinediones. Methods: Analyze the correlated literature at home and abroad. Results: Thiazolidinediones improve insulin sensitivity of patients with insulin resistance and type 2 diabetes mellitus through several mechanisms. Conclusion: Thiazolidinediones are very valuable in clinic, but patient should pay attention to their adverse effects.