妊娠高血压综合征患者血清及新生儿脐血中VCAM-1和TNF-α含量测定的临床意义

Clinical significance of determination of VCAM-1 and TNF-αin serum of patiens with pregnancy-induced hypertension and in cord blood of newborns

目的 :探讨血管细胞粘附分子 (VCAM- 1 )、肿瘤坏死因子 (TNF- α)在妊娠高血压综合征 (妊高征 )发病机理中的作用。方法 :应用酶联免疫方法及放免法测定 6 0例妊高征患者和 2 0例正常妊娠妇女血清及新生儿脐静脉血中 VCAM- 1、TNF- α含量。结果 :妊高征组 VCAM- 1、TNF- α含量较对照组高 ,以中、重度者增高显著 ,与对照组比较差异有显著性 (P<0 .0 5 )。新生儿脐血中 VCAM- 1、 TNF- α含量两组比较差异无显著性。在母体血中VCAM- 1、TNF- α含量具有良好的相关性 (P<0 .0 5 )。结论 :VCAM- 1、TNF-

ObjectiveTo study the role of vascular cell adhesion molecules (VCAM 1) and tumor necrosis factor (TNF α)on the pathogenesis of pregnancy induced hypertension (PIH).MethodsELISA and radioimmunoassay were used to measure the levels of VCAM 1 and TNF α in maternal serum and cord blood of 20 cases of normal pregnant women and 60 cases of PIH women. ResultsThe serum levels of VCAM 1 and TNF α in the moderate and severe PIH group were significantly higher than that in control group ( P <0 05). There was no difference of the levels of VCAM 1 and TNF α in cord blood between PIH and control group. There was significant relativity between VCAM 1 and TNF α in serum of PIH patients ( P <0 05). ConclusionVCAM 1 and TNF α may be important factors in the pathogenesis of PIH.