两种新型聚氨酯涂层材料的血液相容性研究

Blood Compatibility of Two Novel Polyurethane Coating Materials

以十八烷基聚氧乙烯 (SPEO )与 4 ,4 '-二苯甲撑二异氰酸酯 (MDI)的偶联物 SPEO- MDI- SPEO(MSPEO)作为改性材料 ,并分别与聚醚氨酯 (PEU)、壳聚糖 (Chi)两种成膜剂共混得到 MSPEO- PEU、MSPEO- Chi两种改性涂层 ,改性 PEU基膜得到两种改性膜 MSPEO- PEU/PEU(膜 )、MSPEO- Chi/PEU(膜 )。通过血小板黏附实验 ,复钙化时间和凝血酶原时间的测定 ,对比了膜 和膜 的抗凝血性能。结果发现两种改性涂层均可显著提高聚氨酯材料的抗凝血效果 ,并不引发溶血反应 ,是极具潜力的两种新型医用聚氨酯涂层材料。其中 ,膜 对血小板的吸附较多 ,但对延长复钙化时间效果较好 ,膜

Amphiphilic coupling polymer of stearyl poly(ethylene oxide) co 4,4' methylendiphenyl diisocyanate co stearyl poly(ethylene oxide), MSPEO, was specially designed as surface modifying additives. The blends of MSPEO in both polyether urethane (PEU) and chitosan(Chi), as the coating materials for intravascular device were investigated. Two kinds of static clotting time tests, plasma recalcification time(PRT) and prothrombin time(PT), as well as the static platelet adhesion experiment were carried out. And the dynamic anti coagulation experiment was performed with a closed loop tubular system under a blood shear rate of 1 500 s -1 .The results demonstrate that both blend coatings can improve the anti coagulation of polyurethane greatly and will not lead to hemolysis, and that more platelets adhere to the surface modified by Chi MSPEO blend coating as compared with those adhere to the surface modified by PEU MSPEO blend coating. The surface modified by Chi MSPEO has longer PRT, whereas the surface modified by PEU MSPEO has longer PT.