模拟脑电节律的调制磁场对中缝核神经元放电影响的研究

Study on the Influence of Simulative EEG Modulation Magnetic Field on the Discharge of Median Raphe Nuclei

用数值计算和动物实验的方法研究模拟脑电节律的调制磁场对与睡眠有关的中缝核神经元放电的影响 ,从而探讨其对睡眠的影响。通过数字仿真 ,研究了神经纤维对调制磁场刺激作用的响应特性 ,发现了神经纤维具有对低频调制包络信号响应敏感 ,对高频载波不响应的特性。依据睡眠全过程脑电节律的变化 ,研制了模拟 EEG信号发生器。采用高频磁脉冲作为载波调制模拟脑电节律信号 ,用所得的调制磁场诱导兔脑 ,观察磁刺激对中缝核5 -羟色胺能神经元放电的影响。动物实验结果表明 ,中缝核经磁刺激后放电频率发生显著改变 ,其放电变慢。这说明磁刺激能抑制 5 -羟色胺能神经元神经电活动水平 。

In this paper the response characteristic of the nerve fiber to the modulation magnetic field induction is studied by using the method of numeric simulation. It is found that the nerve fiber is sensitive to the low frequency modulated signal but not to the high frequency carrier wave. A simulative EEG signal generator is developed according to the change of EEG rhythm during the sleep. The simulative EEG square wave is modulated by high frequency magnetic impulse. The modulation magnetic field is coupled into the rabbit's brain to study the influence of magnetic stimulation on the discharge of 5 hydroxytryptamine (5 HT) nerve cell. The experiment results demonstrate that discharge frequency of median raphe nuclei related to sleep changes significantly and the discharge becomes slow, which shows that magnetic stimulation can inhibit electrical activity of 5 HT nerve cell and provide a new way to improve insomnia.