胶原基真皮再生支架的微结构控制

Factors Controlling the Microstructure of Collagen-based Dermis Regeneration Scaffold

综述了影响胶原基真皮再生支架微结构的各种因素及其控制方法。胶原基真皮支架的生物活性和修复创面的能力受到诸如除胶原外的其它主要材料 (第二组分 )、支架的孔径和孔隙率、支架厚度、生物活性因子以及交联度等多方面因素的综合影响。从材料学、生物学和医学的角度综合地应用物理、化学和生物学的手段探索各种影响因素的控制方法是组织工程皮肤研究的重点。

The factors controlling the microstructure and properties of collagen based bioactive artificial dermis are reviewed. The second component, the pore diameter and porosity, the thickness of scaffold, the bioactive factors as well as the cross linking density that are important parameters of artificial dermis should be carefully researched and designed. Experiment methods controlling these parameters are suggested.